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Archive (2015–2005)

Time Varying Neonatal Seizure Localization

Journal: Methods of Information in Medicine
Subtitle: A journal stressing, for more than 50 years, the methodology and scientific fundamentals of organizing, representing and analyzing data, information and knowledge in biomedicine and health care
ISSN: 0026-1270

Special Topic: Biosignal Interpretation Conference – BSI 2009 Guest Editors: K. H. Chon, K. Yana

Issue: 2010 (Vol. 49): Issue 5 2010
Pages: 473-478

Time Varying Neonatal Seizure Localization

Special Topic: Biosignal Interpretation

W. Deburchgraeve (1), P. J. Cherian (2), M. De Vos (1), R. M. Swarte (3), J. H. Blok (2), G. H. Visser (2), P. Govaert (3), S. Van Huffel (1)

(1) Department of Electrical Engineering (ESAT), Katholieke Universiteit Leuven, Leuven-Heverlee, Belgium; (2) Department of Clinical Neurophysiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; (3) Department of Neonatology, Sophia Children’s Hospital, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands


CP-decomposition, neonatal EEG, seizure localization


Background: A common cause for damage to the neonatal brain is a shortage in the oxygen supply to the brain or asphyxia. Neonatal seizures are the most frequent manifestation of neonatal neurologic disorders. Multichannel EEG recordings allow topographic localization of seizure foci. Objectives: We want to objectively determine the spatial distribution of the seizure on the scalp, the location in time and order the dominant sources in the brain based on their strength. Methods: In this paper we combine a method based on higher order CP-decomposition with subsequent singular value decomposition (SVD). Results: We illustrate the abilities of the method on simulated as well as on real neonatal seizure EEG. Conclusions: The proposed method provides reliable time and spatial information about the seizure, gives a clear overview of what is going on in the EEG and allows easy interpretation.

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